Friend Virus-induced Reticulum Cell Sarcomas Grown in Vitro" Further Evidence for the Absence of Friend Virus a
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چکیده
Friend virus-induced reticulum cell sarcomas arising in BALB/c and BDF1 mice were grown in tissue culture and tested for the presence of Friend virus. Repeated tests in newborn BALB/c mice failed to detect infectious virus. Immunization with tissue cultures failed to protect mice against challenge with Friend virus or to induce detectable neutralizing antibody to the virus. Electron microscopy revealed small numbers of type-A particles which were thought to be unrelated to Friend virus. No type-C particles were seen. Virus-free cultures could be reinfected both in vivo and in vitro, but the virus again disappeared after prolonged culture. It was concluded that the cultures were free from infectious Friend virus and that the neoplastic properties of the tumor cells were not dependent upon its continued presence.
منابع مشابه
Tumor-specific transplantation antigens in reticulum cell sarcomas and lymphomas induced by the friend virus complex.
The reticulum cell sarcomas induced by Friend leukemia virus (FLV) and the lymphomas induced by the Friend virus-associated lymphatic leukemia virus (LLV) have been investigated for both their antigenic relationships and the presence in them of common tumor-specific transplantation antigens. Since noninfectious reticulum cell sarcomas contain ing the Friend virus genome were available, this was...
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